A74V (p.Ala74Val) variant of AGT (Angiotensinogen)
A74V (p.Ala74Val) in AGT (Angiotensinogen) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
A74V (p.Ala74Val) variant details
- p.Ala74Val
- rs201569036
- NCI-TCGA Cosmic COSV6418
- Ensembl rs201569036
- Likely benign
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.368
- REVEL 0.20
- CADD 14.70
- PolyPhen-2 0.10
- SIFT 0.20
- ClinVar: Likely benign (not provided)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the HGDP:MBUTI population (allele frequency 0.083)
- Structural context available