A4P (p.Ala4Pro) variant of AGT (Angiotensinogen)
A4P (p.Ala4Pro) in AGT (Angiotensinogen) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
A4P (p.Ala4Pro) variant details
- p.Ala4Pro
- TOPMed rs1043140445
- gnomAD rs1043140445
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.315
- REVEL 0.16
- AlphaMissense 0.11
- MetaLR 0.35
- MetaSVM -0.57
- CADD 16.20
- PolyPhen-2 0.62
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 4.4e-05)
- Structural context available