V84F (p.Val84Phe) variant of ADH1B (P00325)
V84F (p.Val84Phe) in ADH1B (P00325) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
V84F (p.Val84Phe) variant details
- p.Val84Phe
- rs762335814
- NCI-TCGA Cosmic COSV5929
- cosmic curated COSV59296
- ExAC rs762335814
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.227
- REVEL 0.09
- CADD 16.30
- PolyPhen-2 0.14
- SIFT 0.33
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available