G87V (p.Gly87Val) variant of ADD1 (Alpha-adducin)
G87V (p.Gly87Val) in ADD1 (Alpha-adducin) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data and structural context.
G87V (p.Gly87Val) variant details
- p.Gly87Val
- NCI-TCGA Cosmic COSV9929
- cosmic curated COSV99296
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.545
- REVEL 0.37
- ESM-1b 1.00
- AlphaMissense 0.54
- MetaLR 0.20
- MetaSVM -0.67
- CADD 28.70
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available