Q102P (p.Gln102Pro) variant of ACE2 (Angiotensin-converting enzyme 2)
Q102P (p.Gln102Pro) in ACE2 (Angiotensin-converting enzyme 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data, experimental measurements, and structural context.
Q102P (p.Gln102Pro) variant details
- p.Gln102Pro
- TOPMed rs1395878099
- gnomAD rs1395878099
- Missense
- Variant Prioritization Score for Impact Estimate 0.247
- REVEL 0.16
- CADD 20.50
- PolyPhen-2 0.02
- SIFT 0.04
- Most common in the 1KG:CLM population (allele frequency 0.0053)
- Structural context available
- ACE2 binding to SARS-CoV-2 spike protein, low affinity: score -0.503