P84T (p.Pro84Thr) variant of ACE2 (Angiotensin-converting enzyme 2)
P84T (p.Pro84Thr) in ACE2 (Angiotensin-converting enzyme 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.06 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P84T (p.Pro84Thr) variant details
- p.Pro84Thr
- ExAC rs759134032
- gnomAD rs759134032
- Missense
- Variant Prioritization Score for Impact Estimate 0.0635
- REVEL 0.06
- CADD 1.89
- PolyPhen-2 0.11
- SIFT 0.14
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- ACE2 binding to SARS-CoV-2 spike protein, low affinity: score 0.0924