N64K (p.Asn64Lys) variant of ACE2 (Angiotensin-converting enzyme 2)
N64K (p.Asn64Lys) in ACE2 (Angiotensin-converting enzyme 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.07 / 1. The record also includes population frequency data, experimental measurements, and structural context.
N64K (p.Asn64Lys) variant details
- p.Asn64Lys
- TOPMed rs1199100713
- gnomAD rs1199100713
- Missense
- Variant Prioritization Score for Impact Estimate 0.0699
- REVEL 0.08
- CADD 0.04
- PolyPhen-2 0.00
- SIFT 0.15
- Most common in the 1KG:CLM population (allele frequency 0.0053)
- Structural context available
- ACE2 binding to SARS-CoV-2 spike protein, low affinity: score -0.792