N51S (p.Asn51Ser) variant of ACE2 (Angiotensin-converting enzyme 2)
N51S (p.Asn51Ser) in ACE2 (Angiotensin-converting enzyme 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data, experimental measurements, and structural context.
N51S (p.Asn51Ser) variant details
- p.Asn51Ser
- Ensembl rs1569243690
- Missense
- Variant Prioritization Score for Impact Estimate 0.354
- REVEL 0.21
- CADD 23.10
- PolyPhen-2 0.48
- SIFT 0.06
- Most common in the HGDP:FRENCH population (allele frequency 0.019)
- Structural context available
- ACE2 binding to SARS-CoV-2 spike protein, low affinity: score -0.928