M62V (p.Met62Val) variant of ACE2 (Angiotensin-converting enzyme 2)
M62V (p.Met62Val) in ACE2 (Angiotensin-converting enzyme 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data, experimental measurements, and structural context.
M62V (p.Met62Val) variant details
- p.Met62Val
- TOPMed rs1325542104
- gnomAD rs1325542104
- Missense
- Variant Prioritization Score for Impact Estimate 0.244
- REVEL 0.12
- CADD 19.20
- PolyPhen-2 0.10
- SIFT 0.08
- Most common in the 1KG:MSL population (allele frequency 0.013)
- Structural context available
- ACE2 binding to SARS-CoV-2 spike protein, low affinity: score -0.246