L186S (p.Leu186Ser) variant of ACE2 (Angiotensin-converting enzyme 2)
L186S (p.Leu186Ser) in ACE2 (Angiotensin-converting enzyme 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data and structural context.
L186S (p.Leu186Ser) variant details
- p.Leu186Ser
- ExAC rs750052167
- gnomAD rs750052167
- Missense
- Variant Prioritization Score for Impact Estimate 0.577
- REVEL 0.57
- CADD 26.20
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available