K68E (p.Lys68Glu) variant of ACE2 (Angiotensin-converting enzyme 2)
K68E (p.Lys68Glu) in ACE2 (Angiotensin-converting enzyme 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, experimental measurements, and structural context.
K68E (p.Lys68Glu) variant details
- p.Lys68Glu
- ExAC rs755691167
- TOPMed rs755691167
- gnomAD rs755691167
- Missense
- Variant Prioritization Score for Impact Estimate 0.125
- REVEL 0.09
- CADD 8.25
- PolyPhen-2 0.01
- SIFT 0.65
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- ACE2 binding to SARS-CoV-2 spike protein, low affinity: score 0.434