K26E (p.Lys26Glu) variant of ACE2 (Angiotensin-converting enzyme 2)
K26E (p.Lys26Glu) in ACE2 (Angiotensin-converting enzyme 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, experimental measurements, and structural context.
K26E (p.Lys26Glu) variant details
- p.Lys26Glu
- gnomAD rs1299103394
- Missense
- Variant Prioritization Score for Impact Estimate 0.124
- REVEL 0.02
- CADD 6.41
- PolyPhen-2 0.00
- SIFT 0.17
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available
- ACE2 binding to SARS-CoV-2 spike protein, low affinity: score -1.72