I21T (p.Ile21Thr) variant of ACE2 (Angiotensin-converting enzyme 2)
I21T (p.Ile21Thr) in ACE2 (Angiotensin-converting enzyme 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.05 / 1. The record also includes population frequency data, experimental measurements, and structural context.
I21T (p.Ile21Thr) variant details
- p.Ile21Thr
- cosmic curated COSV53024
- gnomAD rs1244687367
- Missense
- Variant Prioritization Score for Impact Estimate 0.0533
- REVEL 0.03
- CADD 0.14
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00019)
- Structural context available
- ACE2 binding to SARS-CoV-2 spike protein, low affinity: score 0.217