F72V (p.Phe72Val) variant of ACE2 (Angiotensin-converting enzyme 2)
F72V (p.Phe72Val) in ACE2 (Angiotensin-converting enzyme 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data, experimental measurements, and structural context.
F72V (p.Phe72Val) variant details
- p.Phe72Val
- gnomAD rs1256007252
- Missense
- Variant Prioritization Score for Impact Estimate 0.406
- REVEL 0.30
- CADD 23.40
- PolyPhen-2 0.77
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 8.8e-05)
- Structural context available
- ACE2 binding to SARS-CoV-2 spike protein, low affinity: score 0.255