K15N (p.Lys15Asn) variant of ABL1 (Tyrosine-protein kinase ABL1)
K15N (p.Lys15Asn) in ABL1 (Tyrosine-protein kinase ABL1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
K15N (p.Lys15Asn) variant details
- p.Lys15Asn
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.307
- REVEL 0.28
- MetaLR 0.27
- MetaSVM -0.69
- CADD 18.50
- PolyPhen-2 0.98
- SIFT 0.13
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.6e-05)
- Structural context available