T33I (p.Thr33Ile) variant of ABCB1 (ATP-dependent translocase ABCB1)
T33I (p.Thr33Ile) in ABCB1 (ATP-dependent translocase ABCB1) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as drug response in the context of Tramadol response. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes structural context.
T33I (p.Thr33Ile) variant details
- p.Thr33Ile
- rs1584911173
- ClinGen CA368094132
- ClinVar RCV001028457
- Ensembl rs1584911173
- drug response
- Tramadol response
- Missense
- Variant Prioritization Score for Impact Estimate 0.418
- AlphaMissense 0.15
- MetaLR 0.36
- MetaSVM -0.68
- PolyPhen-2 0.02
- SIFT 0.20
- MutPred 0.24
- ClinVar: drug response (Tramadol response)
- EBI: Drug response
- UniProt: Drug response
- Structural context available