T101I (p.Thr101Ile) variant of ABCB1 (ATP-dependent translocase ABCB1)
T101I (p.Thr101Ile) in ABCB1 (ATP-dependent translocase ABCB1) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as drug response in the context of Tramadol response. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes structural context.
T101I (p.Thr101Ile) variant details
- p.Thr101Ile
- rs1584890130
- ClinGen CA368091648
- ClinVar RCV001029312
- Ensembl rs1584890130
- drug response
- Tramadol response
- Missense
- Variant Prioritization Score for Impact Estimate 0.413
- AlphaMissense 0.13
- MetaLR 0.43
- MetaSVM -0.71
- PolyPhen-2 0.00
- SIFT 0.09
- MutPred 0.57
- ClinVar: drug response (Tramadol response)
- EBI: Drug response
- UniProt: Drug response
- Structural context available