P32T (p.Pro32Thr) variant of ABCB1 (ATP-dependent translocase ABCB1)
P32T (p.Pro32Thr) in ABCB1 (ATP-dependent translocase ABCB1) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as drug response in the context of Tramadol response. The available variant effect predictions contribute to a CATVariant prioritization score of 0.62 / 1. The record also includes population frequency data and structural context.
P32T (p.Pro32Thr) variant details
- p.Pro32Thr
- rs751270575
- ClinGen CA4328693
- ClinVar RCV001028456
- ExAC rs751270575
- drug response
- Tramadol response
- Missense
- Variant Prioritization Score for Impact Estimate 0.62
- CADD 20.70
- PolyPhen-2 0.23
- SIFT 0.24
- ClinVar: drug response (Tramadol response)
- EBI: Drug response
- UniProt: Drug response
- Most common in the South Asian population (allele frequency 2.3e-05)
- Structural context available