M89I (p.Met89Ile) variant of ABCB1 (ATP-dependent translocase ABCB1)
M89I (p.Met89Ile) in ABCB1 (ATP-dependent translocase ABCB1) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as drug response in the context of Tramadol response. The available variant effect predictions contribute to a CATVariant prioritization score of 0.06 / 1. The record also includes population frequency data and structural context.
M89I (p.Met89Ile) variant details
- p.Met89Ile
- rs1584902336
- ClinGen CA368093288
- cosmic curated COSV10505
- ClinVar RCV001029297
- drug response
- Tramadol response
- Missense
- Variant Prioritization Score for Impact Estimate 0.0599
- CADD 0.01
- PolyPhen-2 0.00
- SIFT 0.41
- ClinVar: drug response (Tramadol response)
- EBI: Drug response
- UniProt: Drug response
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available