L65F (p.Leu65Phe) variant of ABCB1 (ATP-dependent translocase ABCB1)
L65F (p.Leu65Phe) in ABCB1 (ATP-dependent translocase ABCB1) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as drug response in the context of Tramadol response. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes structural context.
L65F (p.Leu65Phe) variant details
- p.Leu65Phe
- rs1584902425
- ClinGen CA368093570
- ClinVar RCV001029292
- Ensembl rs1584902425
- drug response
- Tramadol response
- Missense
- Variant Prioritization Score for Impact Estimate 0.494
- AlphaMissense 0.33
- MetaLR 0.45
- MetaSVM -0.02
- PolyPhen-2 0.91
- SIFT 0.12
- MutPred 0.55
- ClinVar: drug response (Tramadol response)
- EBI: Drug response
- UniProt: Drug response
- Structural context available