G62V (p.Gly62Val) variant of ABCB1 (ATP-dependent translocase ABCB1)
G62V (p.Gly62Val) in ABCB1 (ATP-dependent translocase ABCB1) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as drug response in the context of Tramadol response. The available variant effect predictions contribute to a CATVariant prioritization score of 0.83 / 1. The record also includes structural context.
G62V (p.Gly62Val) variant details
- p.Gly62Val
- rs1584902437
- ClinGen CA368093593
- cosmic curated COSV55948
- ClinVar RCV001029291
- drug response
- Tramadol response
- Missense
- Variant Prioritization Score for Impact Estimate 0.834
- AlphaMissense 0.99
- MetaLR 0.76
- MetaSVM 0.76
- PolyPhen-2 1.00
- SIFT 0.01
- MutPred 0.93
- ClinVar: drug response (Tramadol response)
- EBI: Drug response
- UniProt: Drug response
- Structural context available