A82T (p.Ala82Thr) variant of ABCB1 (ATP-dependent translocase ABCB1)
A82T (p.Ala82Thr) in ABCB1 (ATP-dependent translocase ABCB1) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as drug response in the context of Tramadol response. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes structural context.
A82T (p.Ala82Thr) variant details
- p.Ala82Thr
- rs1584902369
- ClinGen CA368093378
- ClinVar RCV001029294
- Ensembl rs1584902369
- drug response
- Tramadol response
- Missense
- Variant Prioritization Score for Impact Estimate 0.356
- AlphaMissense 0.09
- MetaLR 0.21
- MetaSVM -0.95
- PolyPhen-2 0.01
- SIFT 0.39
- MutPred 0.40
- ClinVar: drug response (Tramadol response)
- EBI: Drug response
- UniProt: Drug response
- Structural context available