Mirror movements 1: genes and variants
Mirror movements 1 is linked to 2 analyzed proteins (DCC and RAD51). 3 DNA variants are known to cause it; 7 more are uncertain, and 0 of those already look disease-causing on computable evidence.
Last updated 2026-09-30. Research information, not medical advice.
Also known as: mirror movements 2
Genes linked to Mirror movements 1
DCC: Netrin receptor DCC
It guides developing axons in response to netrin signals and helps establish long-range neural connections across the midline. Heterozygous pathogenic variants can cause congenital mirror movements, while biallelic or severe variants can produce complex neurodevelopmental syndromes.
2 disease-causing and 7 uncertain variants in DCC are linked to Mirror movements 1.
RAD51: DNA repair protein RAD51 homolog 1
1 disease-causing and 0 uncertain variants in RAD51 are linked to Mirror movements 1.
Known disease-causing variants in Mirror movements 1
| Variant | Position | Protein part | Clinical label |
|---|---|---|---|
| RAD51 R250Q | 250 | Nuclear export signal | Disease-causing |
| DCC V793G | 793 | Fibronectin type-III 4 | Disease-causing |
| DCC G805E | 805 | Fibronectin type-III 4 | Disease-causing |
Same protein, different disease
- Corpus callosum, agenesis of is also caused by DCC variants; they fall mostly in different places as the Mirror movements 1 variants (6 disease-causing).
- Fanconi anemia complementation group R is also caused by RAD51 variants; they fall mostly in different places as the Mirror movements 1 variants (3 disease-causing).
Diseases related to Mirror movements 1
- Fanconi anemia, also linked to RAD51
- Carcinoma of colon, also linked to DCC
- Corpus callosum, agenesis of, also linked to DCC
- Fanconi anemia complementation group R, also linked to RAD51
- Gaze palsy, familial horizontal, with progressive scoliosis, 2, also linked to DCC
Frequently asked questions
Which genes are linked to Mirror movements 1?
In CATVariant, Mirror movements 1 is linked to 2 analyzed proteins: DCC (Netrin receptor DCC) and RAD51 (DNA repair protein RAD51 homolog 1).
How many genetic variants are linked to Mirror movements 1?
30 variants: 3 are classified as disease-causing (pathogenic or likely pathogenic) in ClinVar and 7 are of uncertain significance or have conflicting reports.
Which uncertain variants in Mirror movements 1 look disease-causing?
None of the uncertain variants currently reaches the likely-pathogenic range on computable evidence alone.
About this data
Variant–disease links come from ClinVar, Open Targets and UniProt, pooled from the latest public CATVariant analysis of each human protein. Evidence scores use the ACMG/AMP Bayesian points scale with computable criteria only (position among known disease variants, rarity in gnomAD, calibrated predictors, deep mutational scanning); there is no family or patient data, so they prioritise variants for expert review and never classify them.
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