Hemorrhage, intracerebral, susceptibility to: genes and variants
Hemorrhage, intracerebral, susceptibility to is linked to 1 analyzed protein (ACE). 1 DNA variants are known to cause it; 183 more are uncertain, and 0 of those already look disease-causing on computable evidence.
Last updated 2026-09-30. Research information, not medical advice.
Genes linked to Hemorrhage, intracerebral, susceptibility to
ACE: Angiotensin-converting enzyme
A membrane-associated enzyme that removes terminal dipeptides from hormones and signaling peptides, including angiotensin I and bradykinin. By generating angiotensin II and inactivating vasodilators, it helps regulate blood pressure, fluid balance, and aspects of nervous-system signaling.
1 disease-causing and 183 uncertain variants in ACE are linked to Hemorrhage, intracerebral, susceptibility to.
Known disease-causing variants in Hemorrhage, intracerebral, susceptibility to
| Variant | Position | Protein part | Clinical label |
|---|---|---|---|
| ACE M1T | 1 | Disease-causing (★) |
Diseases related to Hemorrhage, intracerebral, susceptibility to
- Alzheimer disease, also linked to ACE
- Type 2 diabetes mellitus, also linked to ACE
- Diabetes mellitus, also linked to ACE
- Myocardial infarction, also linked to ACE
- Renal tubular dysgenesis, also linked to ACE
- Renal tubular dysgenesis of genetic origin, also linked to ACE
- Microvascular complications of diabetes, susceptibility to, 3, also linked to ACE
Frequently asked questions
Which genes are linked to Hemorrhage, intracerebral, susceptibility to?
In CATVariant, Hemorrhage, intracerebral, susceptibility to is linked to 1 analyzed protein: ACE (Angiotensin-converting enzyme).
How many genetic variants are linked to Hemorrhage, intracerebral, susceptibility to?
186 variants: 1 are classified as disease-causing (pathogenic or likely pathogenic) in ClinVar and 183 are of uncertain significance or have conflicting reports.
Which uncertain variants in Hemorrhage, intracerebral, susceptibility to look disease-causing?
None of the uncertain variants currently reaches the likely-pathogenic range on computable evidence alone.
About this data
Variant–disease links come from ClinVar, Open Targets and UniProt, pooled from the latest public CATVariant analysis of each human protein. Evidence scores use the ACMG/AMP Bayesian points scale with computable criteria only (position among known disease variants, rarity in gnomAD, calibrated predictors, deep mutational scanning); there is no family or patient data, so they prioritise variants for expert review and never classify them.
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