Factor XIII, b subunit, deficiency of: genes and variants
Factor XIII, b subunit, deficiency of is linked to 1 analyzed protein (F13B). 1 DNA variants are known to cause it; 30 more are uncertain, and 0 of those already look disease-causing on computable evidence.
Last updated 2026-09-30. Research information, not medical advice.
Genes linked to Factor XIII, b subunit, deficiency of
F13B: Coagulation factor XIII B chain
It circulates bound to the catalytic factor XIII A subunits and stabilizes them in plasma before clotting activation. Biallelic deficiency lowers circulating factor XIII and can cause a bleeding tendency, generally milder than complete F13A1 deficiency.
1 disease-causing and 30 uncertain variants in F13B are linked to Factor XIII, b subunit, deficiency of.
Known disease-causing variants in Factor XIII, b subunit, deficiency of
| Variant | Position | Protein part | Clinical label |
|---|---|---|---|
| F13B C450F | 450 | Sushi 7 | Disease-causing |
Diseases related to Factor XIII, b subunit, deficiency of
- Factor XIII deficiency, also linked to F13B
Frequently asked questions
Which genes are linked to Factor XIII, b subunit, deficiency of?
In CATVariant, Factor XIII, b subunit, deficiency of is linked to 1 analyzed protein: F13B (Coagulation factor XIII B chain).
How many genetic variants are linked to Factor XIII, b subunit, deficiency of?
33 variants: 1 are classified as disease-causing (pathogenic or likely pathogenic) in ClinVar and 30 are of uncertain significance or have conflicting reports.
Which uncertain variants in Factor XIII, b subunit, deficiency of look disease-causing?
None of the uncertain variants currently reaches the likely-pathogenic range on computable evidence alone.
About this data
Variant–disease links come from ClinVar, Open Targets and UniProt, pooled from the latest public CATVariant analysis of each human protein. Evidence scores use the ACMG/AMP Bayesian points scale with computable criteria only (position among known disease variants, rarity in gnomAD, calibrated predictors, deep mutational scanning); there is no family or patient data, so they prioritise variants for expert review and never classify them.
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