Ebv-positive nodal t- and nk-cell lymphoma: genes and variants
Ebv-positive nodal t- and nk-cell lymphoma is linked to 3 analyzed proteins (DNMT3A, TET2 and FBXW7). 1 DNA variants are known to cause it; 0 more are uncertain, and 0 of those already look disease-causing on computable evidence.
Last updated 2026-09-30. Research information, not medical advice.
Genes linked to Ebv-positive nodal t- and nk-cell lymphoma
DNMT3A: DNA (cytosine-5)-methyltransferase 3A
It establishes new DNA methylation patterns during development and hematopoietic differentiation. Somatic variants are common in clonal hematopoiesis and acute myeloid leukemia, while germline variants cause Tatton-Brown-Rahman overgrowth syndrome.
0 disease-causing and 0 uncertain variants in DNMT3A are linked to Ebv-positive nodal t- and nk-cell lymphoma.
TET2: Methylcytosine dioxygenase TET2
It oxidizes methylated cytosines and helps reshape DNA methylation during hematopoietic differentiation. Somatic loss-of-function variants are among the most common drivers of clonal hematopoiesis and occur frequently in myeloid malignancies.
0 disease-causing and 0 uncertain variants in TET2 are linked to Ebv-positive nodal t- and nk-cell lymphoma.
FBXW7: F-box/WD repeat-containing protein 7
1 disease-causing and 0 uncertain variants in FBXW7 are linked to Ebv-positive nodal t- and nk-cell lymphoma.
Weakly linked (only a few uncertain records): STAT3, ACTC1, ALMS1, ANK2, AQP4, AQP7, CACNA1B, CACNA1D and 17 more.
Known disease-causing variants in Ebv-positive nodal t- and nk-cell lymphoma
| Variant | Position | Protein part | Clinical label |
|---|---|---|---|
| FBXW7 M268K | 268 | Disease-causing |
Same protein, different disease
- Developmental delay, hypotonia, and impaired language is also caused by FBXW7 variants; they fall mostly in different places as the Ebv-positive nodal t- and nk-cell lymphoma variants (4 disease-causing).
Diseases related to Ebv-positive nodal t- and nk-cell lymphoma
- Acute myeloid leukemia, also linked to DNMT3A and TET2
- Myelodysplastic syndrome, also linked to DNMT3A and TET2
- Tatton-Brown-Rahman overgrowth syndrome, also linked to DNMT3A
- Multiple myeloma, also linked to DNMT3A
- Paediatric disorders, also linked to DNMT3A
- Heyn-Sproul-Jackson syndrome, also linked to DNMT3A
- Developmental delay, hypotonia, and impaired language, also linked to FBXW7
- Rare genetic intellectual disability, also linked to DNMT3A
Frequently asked questions
Which genes are linked to Ebv-positive nodal t- and nk-cell lymphoma?
In CATVariant, Ebv-positive nodal t- and nk-cell lymphoma is linked to 3 analyzed proteins: DNMT3A (DNA (cytosine-5)-methyltransferase 3A), TET2 (Methylcytosine dioxygenase TET2) and FBXW7 (F-box/WD repeat-containing protein 7).
How many genetic variants are linked to Ebv-positive nodal t- and nk-cell lymphoma?
34 variants: 1 are classified as disease-causing (pathogenic or likely pathogenic) in ClinVar and 0 are of uncertain significance or have conflicting reports.
Which uncertain variants in Ebv-positive nodal t- and nk-cell lymphoma look disease-causing?
None of the uncertain variants currently reaches the likely-pathogenic range on computable evidence alone.
About this data
Variant–disease links come from ClinVar, Open Targets and UniProt, pooled from the latest public CATVariant analysis of each human protein. Evidence scores use the ACMG/AMP Bayesian points scale with computable criteria only (position among known disease variants, rarity in gnomAD, calibrated predictors, deep mutational scanning); there is no family or patient data, so they prioritise variants for expert review and never classify them.
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